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Membrane associated guanylate kinase, WW and PDZ domain containing 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAGI3 ; MAGI-3; dJ730K3.2
External IDs MGI1923484 HomoloGene26431 ChEMBL: 5212 GeneCards: MAGI3 Gene
Species Human Mouse
Entrez 260425 99470
Ensembl ENSG00000081026 ENSMUSG00000052539
UniProt Q5TCQ9 Q9EQJ9
RefSeq (mRNA) NM_001142782 NM_001159354
RefSeq (protein) NP_001136254 NP_001152826
Location (UCSC) Chr 1:
113.93 – 114.23 Mb
Chr 3:
104.01 – 104.22 Mb
PubMed search [1] [2]

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.[1][2][3]


MAGI3 has been shown to interact with PTPRB[4] and PTEN.[2]


  1. ^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877. 
  2. ^ a b Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Aug 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J Biol Chem 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157. 
  3. ^ "Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3". 
  4. ^ Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell. Sci. (England) 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. ISSN 0021-9533. PMID 12615970. 

Further reading[edit]