MALAT1

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Metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Identifiers
Symbols MALAT1 ; HCN; LINC00047; MALAT-1; NCRNA00047; NEAT2; PRO2853
External IDs OMIM607924 GeneCards: MALAT1 Gene
Orthologs
Species Human Mouse
Entrez 378938 72289
Ensembl ENSG00000251562 n/a
UniProt n/a n/a
RefSeq (mRNA) NR_002819 NR_002847
RefSeq (protein) n/a n/a
Location (UCSC) Chr 11:
65.27 – 65.27 Mb
Chr 19:
5.8 – 5.8 Mb
PubMed search [1] [2]
Conserved secondary structure in Metastasis associated lung adenocarcinoma transcript 1
MALAT1 secondary structure.jpg
Predicted secondary structure and sequence conservation of MALAT1
Identifiers
Symbol MALAT1
Rfam RF01871
Other data
RNA type Gene;
Domain(s) Eukaryota;
GO 2000147
SO 0001263


MALAT 1 (metastasis associated lung adenocarcinoma transcript 1) also known as NEAT2 (noncoding nuclear-enriched abundant transcript 2) is a large, infrequently spliced non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus.[1] It regulates the expression of metastasis-associated genes.[2] It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes.[3] MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).[4]

Expression in alcoholic brains[edit]

Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.[5]

See also[edit]

References[edit]

  1. ^ Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A (2007). "A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains". BMC Genomics 8: 39. doi:10.1186/1471-2164-8-39. PMC 1800850. PMID 17270048. 
  2. ^ Gutschner, T; Hämmerle, M; Eissmann, M; Hsu, J; Kim, Y; Hung, G; Revenko, A; Arun, G; Stentrup, M; Gross, M; Zörnig, M; MacLeod, AR; Spector, DL; Diederichs, S (Feb 1, 2013). "The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.". Cancer Research 73 (3): 1180–9. doi:10.1158/0008-5472.CAN-12-2850. PMID 23243023. 
  3. ^ Tano K, Mizuno R, Okada T, et al. (November 2010). "MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes". FEBS Lett. 584 (22): 4575–80. doi:10.1016/j.febslet.2010.10.008. PMID 20937273. 
  4. ^ Chojnowski, JL; Braun, EL (Jul 15, 2012). "An unbiased approach to identify genes involved in development in a turtle with temperature-dependent sex determination.". BMC Genomics 13: 308. doi:10.1186/1471-2164-13-308. PMC 3434017. PMID 22793670. 
  5. ^ Kryger R, Fan L, Wilce PA, Jaquet V (2012). "MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics". Alcohol. doi:10.1016/j.alcohol.2012.04.002. PMID 22560368.  edit

Further reading[edit]

External links[edit]