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Microtubule-associated protein 1B
Symbols MAP1B ; FUTSCH; MAP5; PPP1R102
External IDs OMIM157129 MGI1306778 HomoloGene38111 GeneCards: MAP1B Gene
RNA expression pattern
PBB GE MAP1B 214577 at tn.png
More reference expression data
Species Human Mouse
Entrez 4131 17755
Ensembl ENSG00000131711 ENSMUSG00000052727
UniProt P46821 P14873
RefSeq (mRNA) NM_005909 NM_008634
RefSeq (protein) NP_005900 NP_032660
Location (UCSC) Chr 5:
71.4 – 71.51 Mb
Chr 13:
99.42 – 99.52 Mb
PubMed search [1] [2]

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[1][2]


This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[2]


MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and RASSF1.[4]


  1. ^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC et al. (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920. 
  2. ^ a b "Entrez Gene: MAP1B microtubule-associated protein 1B". 
  3. ^ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913. 
  4. ^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD et al. (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320. 

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