MAP1B

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Microtubule-associated protein 1B
Identifiers
Symbols MAP1B ; FUTSCH; MAP5; PPP1R102
External IDs OMIM157129 MGI1306778 HomoloGene38111 GeneCards: MAP1B Gene
RNA expression pattern
PBB GE MAP1B 214577 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4131 17755
Ensembl ENSG00000131711 ENSMUSG00000052727
UniProt P46821 P14873
RefSeq (mRNA) NM_005909 NM_008634
RefSeq (protein) NP_005900 NP_032660
Location (UCSC) Chr 5:
71.4 – 71.51 Mb
Chr 13:
99.42 – 99.52 Mb
PubMed search [1] [2]

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[1][2]

Function[edit]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[2]

Interactions[edit]

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and RASSF1.[4]

References[edit]

  1. ^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC et al. (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920. 
  2. ^ a b "Entrez Gene: MAP1B microtubule-associated protein 1B". 
  3. ^ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913. 
  4. ^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD et al. (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320. 

Further reading[edit]