Microtubule-associated protein 2

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Culture of rat brain cells stained with antibody to MAP2 (green), Neurofilament NF-H (red) and DNA (blue). MAP2 is found in neuronal dendrites, while the neurofilament is found predominantly in axons. Antibodies and image courtesy of EnCor Biotechnology

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Microtubule-associated protein 2
Identifiers
Symbols MAP2 ; MAP2A; MAP2B; MAP2C
External IDs OMIM157130 MGI97175 HomoloGene1779 GeneCards: MAP2 Gene
RNA expression pattern
PBB GE MAP2 210015 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4133 17756
Ensembl ENSG00000078018 ENSMUSG00000015222
UniProt P11137 P20357
RefSeq (mRNA) NM_001039538 NM_001039934
RefSeq (protein) NP_001034627 NP_001035023
Location (UCSC) Chr 2:
210.29 – 210.6 Mb
Chr 1:
66.18 – 66.44 Mb
PubMed search [1] [2]

Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.[1][2]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neuritogenesis. MAP2 serves to stabilize microtubules (MT) growth by crosslinking MT with intermediate filaments and other MTs. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.[3]

Interactions[edit]

MAP2 has been shown to interact with Grb2,[4][5] NEFL[6] and MYO7A.[7] MAP2 is suspected of interacting with tubulin.

References[edit]

  1. ^ Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2". Brain Res 387 (3): 271–80. PMID 3103857. 
  2. ^ Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms". Proc Natl Acad Sci U S A 92 (24): 10894–8. doi:10.1073/pnas.92.24.10894. PMC 40537. PMID 7479905. 
  3. ^ "Entrez Gene: MAP2 microtubule-associated protein 2". 
  4. ^ Lim, R W; Halpain S (July 2000). "Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein". J. Biol. Chem. (UNITED STATES) 275 (27): 20578–87. doi:10.1074/jbc.M001887200. ISSN 0021-9258. PMID 10781592. 
  5. ^ Zamora-Leon, S P; Lee G; Davies P; Shafit-Zagardo B (October 2001). "Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2". J. Biol. Chem. (United States) 276 (43): 39950–8. doi:10.1074/jbc.M107807200. ISSN 0021-9258. PMID 11546790. 
  6. ^ Frappier, T; Stetzkowski-Marden F; Pradel L A (April 1991). "Interaction domains of neurofilament light chain and brain spectrin". Biochem. J. (ENGLAND). 275 ( Pt 2) (Pt 2): 521–7. ISSN 0264-6021. PMC 1150082. PMID 1902666. 
  7. ^ Todorov, P T; Hardisty R E; Brown S D (March 2001). "Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)". Biochem. J. (England) 354 (Pt 2): 267–74. doi:10.1042/0264-6021:3540267. ISSN 0264-6021. PMC 1221652. PMID 11171103. 

Further reading[edit]

  • Roses AD, Einstein G, Gilbert J, et al. (1996). "Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism". Ann. N. Y. Acad. Sci. 777: 146–57. doi:10.1111/j.1749-6632.1996.tb34413.x. PMID 8624078. 
  • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha) 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639. 
  • Shafit-Zagardo B, Kalcheva N (1999). "Making sense of the multiple MAP-2 transcripts and their role in the neuron". Mol. Neurobiol. 16 (2): 149–62. doi:10.1007/BF02740642. PMID 9588626. 
  • Liu Y, Saad RS, Shen SS, Silverman JF (2003). "Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms". Advances in anatomic pathology 10 (2): 101–6. doi:10.1097/00125480-200303000-00005. PMID 12605092. 
  • Ainsztein AM, Purich DL (1992). "Cleavage of bovine brain microtubule-associated protein-2 by human immunodeficiency virus proteinase". J. Neurochem. 59 (3): 874–80. doi:10.1111/j.1471-4159.1992.tb08325.x. PMID 1494913. 
  • Alberts MJ, Kandt RS, Pericak-Vance MA, et al. (1991). "MspI RFLP for microtubule associated protein-2 (MAP2)". Nucleic Acids Res. 19 (4): 960. doi:10.1093/nar/19.4.960. PMC 333743. PMID 1708129. 
  • Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases". J. Gen. Virol. 71 ( Pt 9) (9): 1985–91. doi:10.1099/0022-1317-71-9-1985. PMID 2212989. 
  • Kosik KS, Orecchio LD, Bakalis S, et al. (1988). "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles". J. Neurochem. 51 (2): 587–98. doi:10.1111/j.1471-4159.1988.tb01079.x. PMID 2455776. 
  • Dammerman M, Yen SH, Shafit-Zagardo B (1990). "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles". J. Neurosci. Res. 24 (4): 487–95. doi:10.1002/jnr.490240405. PMID 2481044. 
  • Obar RA, Dingus J, Bayley H, Vallee RB (1990). "The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C". Neuron 3 (5): 639–45. doi:10.1016/0896-6273(89)90274-2. PMID 2561973. 
  • Rubino HM, Dammerman M, Shafit-Zagardo B, Erlichman J (1990). "Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2". Neuron 3 (5): 631–8. doi:10.1016/0896-6273(89)90273-0. PMID 2701845. 
  • Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin". J. Biol. Chem. 262 (3): 1320–5. PMID 3027087. 
  • Garner CC, Tucker RP, Matus A (1989). "Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites". Nature 336 (6200): 674–7. doi:10.1038/336674a0. PMID 3200318. 
  • Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain". FEBS Lett. 372 (1): 59–64. doi:10.1016/0014-5793(95)00955-9. PMID 7556643. 
  • Kindler S, Garner CC (1995). "Four repeat MAP2 isoforms in human and rat brain". Brain Res. Mol. Brain Res. 26 (1–2): 218–24. doi:10.1016/0169-328X(94)90093-0. PMID 7854050. 
  • Albala JS, Kalcheva N, Shafit-Zagardo B (1994). "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)". Gene 136 (1–2): 377–8. doi:10.1016/0378-1119(93)90502-T. PMID 8294038. 
  • Illenberger S, Drewes G, Trinczek B, et al. (1996). "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics". J. Biol. Chem. 271 (18): 10834–43. doi:10.1074/jbc.271.18.10834. PMID 8631898. 
  • Björkblom B, Ostman N, Hongisto V, et al. (2005). "Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector". J Neurosci. 25 (27): 6350–61. doi:10.1523/JNEUROSCI.1517-05.2005. PMID 16000625.