MAP2K2

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Mitogen-activated protein kinase kinase 2
Protein MAP2K2 PDB 1s9i.png
PDB rendering based on 1s9i.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAP2K2 ; MAPKK2; MEK2; MKK2; PRKMK2
External IDs OMIM601263 MGI1346867 HomoloGene48591 ChEMBL: 2964 GeneCards: MAP2K2 Gene
EC number 2.7.12.2
RNA expression pattern
PBB GE MAP2K2 202424 at tn.png
PBB GE MAP2K2 213490 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5605 26396
Ensembl ENSG00000126934 ENSMUSG00000035027
UniProt P36507 Q63932
RefSeq (mRNA) NM_030662.3 NM_023138.4
RefSeq (protein) NP_109587.1 NP_075627.2
Location (UCSC) Chr 19:
4.09 – 4.12 Mb
Chr 10:
80.57 – 80.59 Mb
PubMed search [1] [2]

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[1]

Function[edit]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[2]

Interactions[edit]

MAP2K2 has been shown to interact with MAPK3[3][4][5] and ARAF.[6]

References[edit]

  1. ^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 11435–9. PMID 8388392. 
  2. ^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2". 
  3. ^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895. 
  4. ^ Butch, E R; Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767. 
  5. ^ Zheng, C F; Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. ISSN 0021-9258. PMID 8226933. 
  6. ^ Yin, Xiang L; Chen She; Yan Jun; Hu Yun; Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta (Netherlands) 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642. 

Further reading[edit]

External links[edit]