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Mitogen-activated protein kinase kinase 5
Protein MAP2K5 PDB 1wi0.png
PDB rendering based on 1wi0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAP2K5 ; HsT17454; MAPKK5; MEK5; PRKMK5
External IDs OMIM602520 MGI1346345 HomoloGene115933 ChEMBL: 4948 GeneCards: MAP2K5 Gene
EC number
RNA expression pattern
PBB GE MAP2K5 204756 at tn.png
PBB GE MAP2K5 210482 x at tn.png
PBB GE MAP2K5 211370 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5607 23938
Ensembl ENSG00000137764 ENSMUSG00000058444
UniProt Q13163 Q9WVS7
RefSeq (mRNA) NM_001206804 NM_011840
RefSeq (protein) NP_001193733 NP_035970
Location (UCSC) Chr 15:
67.84 – 68.1 Mb
Chr 9:
63.16 – 63.38 Mb
PubMed search [1] [2]

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.[1][2]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[2]


This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).


This kinase specifically interacts with and activates MAPK7/ERK5.


MAP2K5 has been shown to interact with MAPK7,[1] MAP3K2,[3] Protein kinase Mζ[4] and MAP3K3.[3][5]


  1. ^ a b Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J Biol Chem 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517. 
  2. ^ a b "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5". 
  3. ^ a b Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (Feb 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. (United States) 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940. 
  4. ^ Diaz-Meco, M T; Moscat J (Feb 2001). "MEK5, a New Target of the Atypical Protein Kinase C Isoforms in Mitogenic Signaling". Mol. Cell. Biol. (United States) 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. ISSN 0270-7306. PMC 99575. PMID 11158308. 
  5. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 

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