MAP3K10

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Mitogen-activated protein kinase kinase kinase 10
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAP3K10 ; MEKK10; MLK2; MST
External IDs OMIM600137 MGI1346879 HomoloGene1834 ChEMBL: 2873 GeneCards: MAP3K10 Gene
EC number 2.7.11.25
RNA expression pattern
PBB GE MAP3K10 206362 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4294 269881
Ensembl ENSG00000130758 ENSMUSG00000040390
UniProt Q02779 Q66L42
RefSeq (mRNA) NM_002446 NM_001081292
RefSeq (protein) NP_002437 NP_001074761
Location (UCSC) Chr 19:
40.7 – 40.72 Mb
Chr 7:
27.66 – 27.67 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[3]

Interactions[edit]

MAP3K10 has been shown to interact with NEUROD1,[4] Huntingtin,[5] MAPK8IP1,[6] KIF3A,[7] CDC42[7] and MAPK8IP2.[6]

References[edit]

  1. ^ Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694. 
  2. ^ Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene 10 (7): 1447–51. PMID 7731697. 
  3. ^ a b "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10". 
  4. ^ Marcora, Edoardo; Gowan Katherine; Lee Jacqueline E (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (16): 9578–83. doi:10.1073/pnas.1133382100. ISSN 0027-8424. PMC 170960. PMID 12881483. 
  5. ^ Liu, Y F; Dorow D; Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. (UNITED STATES) 275 (25): 19035–40. doi:10.1074/jbc.C000180200. ISSN 0021-9258. PMID 10801775. 
  6. ^ a b Yasuda, J; Whitmarsh A J; Cavanagh J; Sharma M; Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7245–54. ISSN 0270-7306. PMC 84717. PMID 10490659. 
  7. ^ a b Nagata, K i; Puls A; Futter C; Aspenstrom P; Schaefer E; Nakata T; Hirokawa N; Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. (ENGLAND) 17 (1): 149–58. doi:10.1093/emboj/17.1.149. ISSN 0261-4189. PMC 1170366. PMID 9427749. 

Further reading[edit]