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"MLK3" redirects here. For the American activist, see Martin Luther King III.
Mitogen-activated protein kinase kinase kinase 11
Symbols MAP3K11 ; MEKK11; MLK-3; MLK3; PTK1; SPRK
External IDs OMIM600050 MGI1346880 HomoloGene37618 ChEMBL: 2708 GeneCards: MAP3K11 Gene
EC number
RNA expression pattern
PBB GE MAP3K11 203652 at tn.png
More reference expression data
Species Human Mouse
Entrez 4296 26403
Ensembl ENSG00000173327 ENSMUSG00000004054
UniProt Q16584 Q80XI6
RefSeq (mRNA) NM_002419 NM_022012
RefSeq (protein) NP_002410 NP_071295
Location (UCSC) Chr 11:
65.37 – 65.38 Mb
Chr 19:
5.69 – 5.7 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.[1][2]

The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.[3][4]


MAP3K11 has been shown to interact with MAPK8IP1,[5] CDC42,[6][7] SH3RF1,[8] MAPK8IP2[5] and AKT1.[9]


  1. ^ Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (October 1997). "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807. 
  2. ^ Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (June 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene 9 (6): 1745–50. PMID 8183572. 
  3. ^ Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ (Oct 1, 2011). "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev 25 (19): 2069–78. doi:10.1101/gad.17224711. PMC 3197205. PMID 21979919. 
  4. ^ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11". 
  5. ^ a b Yasuda, J; Whitmarsh A J; Cavanagh J; Sharma M; Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7245–54. ISSN 0270-7306. PMC 84717. PMID 10490659. 
  6. ^ Nagata, K i; Puls A; Futter C; Aspenstrom P; Schaefer E; Nakata T; Hirokawa N; Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. (ENGLAND) 17 (1): 149–58. doi:10.1093/emboj/17.1.149. ISSN 0261-4189. PMC 1170366. PMID 9427749. 
  7. ^ Böck, B C; Vacratsis P O; Qamirani E; Gallo K A (May 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. (UNITED STATES) 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. ISSN 0021-9258. PMID 10799501. 
  8. ^ Figueroa, Claudia; Tarras Samantha; Taylor Jennifer; Vojtek Anne B (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. (United States) 278 (48): 47922–7. doi:10.1074/jbc.M307357200. ISSN 0021-9258. PMID 14504284. 
  9. ^ Barthwal, Manoj K; Sathyanarayana Pradeep; Kundu Chanakya N; Rana Basabi; Pradeep Anamika; Sharma Chandan; Woodgett James R; Rana Ajay (February 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. (United States) 278 (6): 3897–902. doi:10.1074/jbc.M211598200. ISSN 0021-9258. PMID 12458207. 

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