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Mitogen-activated protein kinase kinase kinase 13
Symbols MAP3K13 ; LZK; MEKK13; MLK
External IDs OMIM604915 MGI2444243 HomoloGene37958 ChEMBL: 1163124 GeneCards: MAP3K13 Gene
EC number
RNA expression pattern
PBB GE MAP3K13 206249 at tn.png
PBB GE MAP3K13 211083 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9175 71751
Ensembl ENSG00000073803 ENSMUSG00000033618
UniProt O43283 Q1HKZ5
RefSeq (mRNA) NM_001242314 NM_172821
RefSeq (protein) NP_001229243 NP_766409
Location (UCSC) Chr 3:
185 – 185.21 Mb
Chr 16:
21.89 – 21.93 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.[1][2]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.[2]


MAP3K13 has been shown to interact with PRDX3.[3]


  1. ^ Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328. 
  2. ^ a b "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13". 
  3. ^ Masaki, Megumi; Ikeda Atsushi; Shiraki Eriko; Oka Shogo; Kawasaki Toshisuke (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. (Germany) 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. ISSN 0014-2956. PMID 12492477. 

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