Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13gene.
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
^Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID9353328.
Ikeda A, Sakuma H, Masaki M et al. (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys.6 (2): 113–7. doi:10.1080/10258140290027243. PMID12186766.
Ikeda A, Hasegawa K, Masaki M et al. (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem.130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID11726277.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ.4 (10): 821–30. PMID8274451.