MAP3K13

Mitogen-activated protein kinase kinase kinase 13
Identifiers
Symbols	MAP3K13; LZK; MEKK13; MLK
External IDs	OMIM: 604915 MGI: 2444243 HomoloGene: 37958 GeneCards: MAP3K13 Gene
EC number	2.7.11.25
Gene Ontology Molecular function • nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • protein kinase binding • identical protein binding • protein homodimerization activity Cellular component • membrane fraction • cytoplasm • IkappaB kinase complex • membrane Biological process • activation of MAPKK activity • protein phosphorylation • JNK cascade • JNK cascade • protein autophosphorylation • positive regulation of NF-kappaB transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9175	71751
Ensembl	ENSG00000073803	ENSMUSG00000033618
UniProt	O43283	Q1HKZ5
RefSeq (mRNA)	NM_001242314.1	NM_172821.3
RefSeq (protein)	NP_001229243.1	NP_766409.2
Location (UCSC)	Chr 3: 185 – 185.21 Mb	Chr 16: 21.89 – 21.93 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.

Interactions

MAP3K13 has been shown to interact with PRDX3.

Further reading

• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Masaki M, Ikeda A, Shiraki E et al (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ikeda A, Sakuma H, Masaki M et al (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. doi:10.1080/10258140290027243. PMID 12186766. 
• Ikeda A, Hasegawa K, Masaki M et al (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. PMID 11726277. 
• Ikeda A, Masaki M, Kozutsumi Y et al (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. doi:10.1016/S0014-5793(00)02432-7. PMID 11163770. 
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.