MAP3K2

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Mitogen-activated protein kinase kinase kinase 2
Protein MAP3K2 PDB 2cu1.png
PDB rendering based on 2cu1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAP3K2 ; MEKK2; MEKK2B
External IDs OMIM609487 MGI1346873 HomoloGene74576 ChEMBL: 5914 GeneCards: MAP3K2 Gene
EC number 2.7.11.25
RNA expression pattern
PBB GE MAP3K2 221695 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10746 26405
Ensembl ENSG00000169967 ENSMUSG00000024383
UniProt Q9Y2U5 Q61083
RefSeq (mRNA) NM_006609 NM_011946
RefSeq (protein) NP_006600 NP_036076
Location (UCSC) Chr 2:
128.06 – 128.15 Mb
Chr 18:
32.16 – 32.24 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.[1][2][3]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.[3]

Interactions[edit]

MAP3K2 has been shown to interact with SH2D2A,[4] MAP2K7,[5] MAP2K5,[4] XIAP[6] and MAPK8.[5]

References[edit]

  1. ^ Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (June 1996). "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase". J Biol Chem 271 (10): 5361–8. doi:10.1074/jbc.271.10.5361. PMID 8621389. 
  2. ^ Zhao Q, Lee FS (April 1999). "Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta". J Biol Chem 274 (13): 8355–8. doi:10.1074/jbc.274.13.8355. PMID 10085062. 
  3. ^ a b "Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2". 
  4. ^ a b Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. (United States) 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940. 
  5. ^ a b Cheng, J; Yang J; Xia Y; Karin M; Su B (April 2000). "Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation". Mol. Cell. Biol. (UNITED STATES) 20 (7): 2334–42. doi:10.1128/MCB.20.7.2334-2342.2000. ISSN 0270-7306. PMC 85399. PMID 10713157. 
  6. ^ Winsauer, Gabriele; Resch Ulrike, Hofer-Warbinek Renate, Schichl Yvonne M, de Martin Rainer (November 2008). "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2". Cell. Signal. (England) 20 (11): 2107–12. doi:10.1016/j.cellsig.2008.08.004. ISSN 0898-6568. PMID 18761086. 

Further reading[edit]