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Microtubule-associated protein 4
Symbols MAP4 ; DKFZp779A1753; MGC8617
External IDs OMIM157132 MGI97178 HomoloGene1780 GeneCards: MAP4 Gene
Species Human Mouse
Entrez 4134 17758
Ensembl ENSG00000047849 ENSMUSG00000032479
UniProt P27816 P27546
RefSeq (mRNA) NM_001134364 NM_001205330
RefSeq (protein) NP_001127836 NP_001192259
Location (UCSC) Chr 3:
47.89 – 48.13 Mb
Chr 9:
109.93 – 110.08 Mb
PubMed search [1] [2]

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[1]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.[2] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.[3] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.[4] mMAP4 is a muscle-specific isoform.[4][5]


  1. ^ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98. ( Pt 1): 27–36. PMID 1905296. 
  2. ^ "Entrez Gene: MAP4 microtubule-associated protein 4". 
  3. ^ Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. 
  4. ^ a b Mogessie, Binyam; Roth, Daniel; Rahil, Zainab; Straube, Anne (21 April 2015). "A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation". eLife 4. doi:10.7554/eLife.05697. PMID 25898002. 
  5. ^ Casey, LM; Lyon, HD; Olmsted, JB (April 2003). "Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization.". Cell motility and the cytoskeleton 54 (4): 317–36. PMID 12601693. 

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