MAPK10

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Mitogen-activated protein kinase 10
Protein MAPK10 PDB 1jnk.png
PDB rendering based on 1jnk.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPK10 ; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
External IDs OMIM602897 MGI1346863 HomoloGene56439 ChEMBL: 2637 GeneCards: MAPK10 Gene
EC number 2.7.11.24
RNA expression pattern
PBB GE MAPK10 204813 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5602 26414
Ensembl ENSG00000109339 ENSMUSG00000046709
UniProt P53779 Q80W82
RefSeq (mRNA) NM_002753 NM_001081567
RefSeq (protein) NP_002744 NP_001075036
Location (UCSC) Chr 4:
86.94 – 87.52 Mb
Chr 5:
102.91 – 103.21 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions[edit]

MAPK10 has been shown to interact with MAPK8IP3.[4][5][6]

References[edit]

  1. ^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J 15 (11): 2760–70. PMC 450211. PMID 8654373. 
  2. ^ Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J Hum Genet 47 (11): 0614–0619. doi:10.1007/s100380200094. PMID 12436199. 
  3. ^ a b "Entrez Gene: MAPK10 mitogen-activated protein kinase 10". 
  4. ^ Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. PMC 84763. PMID 10523642. 
  5. ^ Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060. 
  6. ^ Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. PMID 12189133. 

External links[edit]


Further reading[edit]