From Wikipedia, the free encyclopedia
Jump to: navigation, search
Mitogen-activated protein kinase 11
Protein MAPK11 PDB 3GC8.png
Rendering based on PDB 3GC8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAPK11 ; P38B; P38BETA2; PRKM11; SAPK2; SAPK2B; p38-2; p38Beta
External IDs OMIM602898 MGI1338024 HomoloGene55684 ChEMBL: 3961 GeneCards: MAPK11 Gene
EC number
RNA expression pattern
PBB GE MAPK11 211499 s at tn.png
PBB GE MAPK11 206040 s at tn.png
PBB GE MAPK11 211500 at tn.png
More reference expression data
Species Human Mouse
Entrez 5600 19094
Ensembl ENSG00000185386 ENSMUSG00000053137
UniProt Q15759 Q9WUI1
RefSeq (mRNA) NM_002751 NM_011161
RefSeq (protein) NP_002742 NP_035291
Location (UCSC) Chr 22:
50.7 – 50.71 Mb
Chr 15:
89.14 – 89.15 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.[1][2]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.[2]


MAPK11 has been shown to interact with HDAC3[3] and Promyelocytic leukemia protein.[4]

See also[edit]


  1. ^ Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". EMBO J 16 (12): 3563–71. doi:10.1093/emboj/16.12.3563. PMC 1169981. PMID 9218798. 
  2. ^ a b "Entrez Gene: MAPK11 mitogen-activated protein kinase 11". 
  3. ^ Mahlknecht, Ulrich; Will Jutta, Varin Audrey, Hoelzer Dieter, Herbein Georges (Sep 2004). "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. (United States) 173 (6): 3979–90. ISSN 0022-1767. PMID 15356147. 
  4. ^ Shin, Jinwook; Park Boyoun, Cho Sunglim, Lee Sunray, Kim Youngkyun, Lee Seong-Ok, Cho Kwangmin, Lee Sungwook, Jin Bong-Suk, Ahn Jin-Hyun, Choi Eui-Ju, Ahn Kwangseog (Sep 2004). "Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase". J. Biol. Chem. (United States) 279 (39): 40994–1003. doi:10.1074/jbc.M407369200. ISSN 0021-9258. PMID 15273249. 

External links[edit]

Further reading[edit]