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Mitogen-activated protein kinase 6
Protein MAPK6 PDB 2i6l.png
PDB rendering based on 2i6l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAPK6 ; ERK3; HsT17250; PRKM6; p97MAPK
External IDs OMIM602904 MGI1354946 HomoloGene55683 IUPHAR: 2092 ChEMBL: 5121 GeneCards: MAPK6 Gene
EC number
RNA expression pattern
PBB GE MAPK6 207121 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5597 50772
Ensembl ENSG00000069956 ENSMUSG00000042688
UniProt Q16659 Q61532
RefSeq (mRNA) NM_002748 NM_015806
RefSeq (protein) NP_002739 NP_056621
Location (UCSC) Chr 15:
52.24 – 52.36 Mb
Chr 9:
75.37 – 75.41 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.[1][2]

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.[2]


  1. ^ Meloche S, Beatty BG, Pellerin J (Dec 1996). "Primary structure, expression and chromosomal locus of a human homolog of rat ERK3". Oncogene 13 (7): 1575–9. PMID 8875998. 
  2. ^ a b "Entrez Gene: MAPK6 mitogen-activated protein kinase 6". 

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