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Mitogen-activated protein kinase 8 interacting protein 2
Symbols MAPK8IP2 ; IB-2; IB2; JIP2; PRKM8IPL
External IDs OMIM607755 MGI1926555 HomoloGene8201 GeneCards: MAPK8IP2 Gene
RNA expression pattern
PBB GE MAPK8IP2 205050 s at tn.png
PBB GE MAPK8IP2 208603 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23542 60597
Ensembl ENSG00000008735 ENSMUSG00000022619
UniProt Q13387 Q9ERE9
RefSeq (mRNA) NM_012324 NM_021921
RefSeq (protein) NP_036456 NP_068740
Location (UCSC) Chr 22:
51.04 – 51.05 Mb
Chr 15:
89.45 – 89.46 Mb
PubMed search [1] [2]

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it.[1][2] The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses,[3] and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[2]


MAPK8IP2 has been shown to interact with MAP3K10,[1] Mitogen-activated protein kinase 9,[1] LRP2,[4][5] LRP1,[4] MAPK8IP3,[6] MAP3K12,[1] MAPK8IP1,[1] MAP2K7[1][7] and MAP3K11.[1]


  1. ^ a b c d e f g Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (February 2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol Cell Biol 19 (10): 7245–54. PMC 84717. PMID 10490659. 
  2. ^ a b "Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2". 
  3. ^ Giza J et al. (2010). "Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.". J Neurosci. 30 (44): 14805–16. doi:10.1523/JNEUROSCI.1161-10.2010. PMC 3200367. PMID 21048139. 
  4. ^ a b Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. (UNITED STATES) 275 (33): 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173. 
  5. ^ Petersen, Helle Heibroch; Hilpert Jan; Militz Daniel; Zandler Valerie; Jacobsen Christian; Roebroek Anton J M; Willnow Thomas E (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. (England) 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. ISSN 0021-9533. PMID 12508107. 
  6. ^ Kelkar, N; Gupta S; Dickens M; Davis R J (February 2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. ISSN 0270-7306. PMC 85220. PMID 10629060. 
  7. ^ Negri, S; Oberson A; Steinmann M; Sauser C; Nicod P; Waeber G; Schorderet D F; Bonny C (March 2000). "cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein". Genomics (UNITED STATES) 64 (3): 324–30. doi:10.1006/geno.2000.6129. ISSN 0888-7543. PMID 10756100. 

Further reading[edit]