MAPKAPK2

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Mitogen-activated protein kinase-activated protein kinase 2
Protein MAPKAPK2 PDB 1kwp.png
PDB rendering based on 1kwp.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPKAPK2 ; MAPKAP-K2; MK-2; MK2
External IDs OMIM602006 MGI109298 HomoloGene56412 ChEMBL: 2208 GeneCards: MAPKAPK2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE MAPKAPK2 201460 at tn.png
PBB GE MAPKAPK2 201461 s at tn.png
PBB GE MAPKAPK2 215050 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9261 17164
Ensembl ENSG00000162889 ENSMUSG00000016528
UniProt P49137 P49138
RefSeq (mRNA) NM_004759 NM_008551
RefSeq (protein) NP_004750 NP_032577
Location (UCSC) Chr 1:
206.86 – 206.91 Mb
Chr 1:
131.05 – 131.1 Mb
PubMed search [1] [2]

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.[1][2]

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.[3]

See also[edit]

  • SB 203580, suppresses the activation of MAPKAPK2

Interactions[edit]

MAPKAPK2 has been shown to interact with MAPK14,[4][5] AKT1,[4] PHC2[6] and SHC1.[6]

References[edit]

  1. ^ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (Jun 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochem Biophys Res Commun 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591. 
  2. ^ Stokoe D, Caudwell B, Cohen PT, Cohen P (Feb 1994). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". Biochem J 296 (Pt 3): 843–9. PMC 1137771. PMID 8280084. 
  3. ^ "Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2". 
  4. ^ a b Rane, M J; Coxon P Y, Powell D W, Webster R, Klein J B, Pierce W, Ping P, McLeish K R (Feb 2001). "p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils". J. Biol. Chem. (United States) 276 (5): 3517–23. doi:10.1074/jbc.M005953200. ISSN 0021-9258. PMID 11042204. 
  5. ^ Janknecht, R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". J. Biol. Chem. (United States) 276 (45): 41856–61. doi:10.1074/jbc.M106630200. ISSN 0021-9258. PMID 11551945. 
  6. ^ a b Yannoni, Yvonne M; Gaestel Matthias, Lin Lih-Ling (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Lett. (Netherlands) 564 (1–2): 205–11. doi:10.1016/S0014-5793(04)00351-5. ISSN 0014-5793. PMID 15094067. 

Further reading[edit]