MAPKAPK3

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Mitogen-activated protein kinase-activated protein kinase 3
Protein MAPKAPK3 PDB 3FHR.png
Rendering based on PDB 3FHR.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPKAPK3 ; 3PK; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MK-3
External IDs OMIM602130 MGI2143163 HomoloGene55836 ChEMBL: 4670 GeneCards: MAPKAPK3 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE MAPKAPK3 202787 s at tn.png
PBB GE MAPKAPK3 202788 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7867 102626
Ensembl ENSG00000114738 ENSMUSG00000032577
UniProt Q16644 Q3UMW7
RefSeq (mRNA) NM_001243925 NM_178907
RefSeq (protein) NP_001230854 NP_849238
Location (UCSC) Chr 3:
50.65 – 50.69 Mb
Chr 9:
107.25 – 107.29 Mb
PubMed search [1] [2]

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.[1][2][3]

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.[3]

Interactions[edit]

MAPKAPK3 has been shown to interact with MAPK14[4] and TCF3.[5]

References[edit]

  1. ^ McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR (June 1996). "Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase". J Biol Chem 271 (14): 8488–92. doi:10.1074/jbc.271.14.8488. PMID 8626550. 
  2. ^ Sithanandam G, Latif F, Duh FM, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S (June 1996). "3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region". Mol Cell Biol 16 (3): 868–76. PMC 231067. PMID 8622688. 
  3. ^ a b "Entrez Gene: MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3". 
  4. ^ Tanoue, T; Maeda R; Adachi M; Nishida E (February 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. (England) 20 (3): 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753. 
  5. ^ Neufeld, B; Grosse-Wilde A; Hoffmeyer A; Jordan B W; Chen P; Dinev D; Ludwig S; Rapp U R (July 2000). "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". J. Biol. Chem. (UNITED STATES) 275 (27): 20239–42. doi:10.1074/jbc.C901040199. ISSN 0021-9258. PMID 10781029. 

Further reading[edit]