MAPRE1

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Microtubule-associated protein, RP/EB family, member 1
Protein MAPRE1 PDB 1pa7.png
PDB rendering based on 1pa7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPRE1 ; EB1
External IDs OMIM603108 MGI891995 HomoloGene56129 GeneCards: MAPRE1 Gene
RNA expression pattern
PBB GE MAPRE1 200713 s at tn.png
PBB GE MAPRE1 200712 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22919 13589
Ensembl ENSG00000101367 ENSMUSG00000027479
UniProt Q15691 Q61166
RefSeq (mRNA) NM_012325 NM_007896
RefSeq (protein) NP_036457 NP_031922
Location (UCSC) Chr 20:
31.41 – 31.44 Mb
Chr 2:
153.74 – 153.77 Mb
PubMed search [1] [2]

Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.[1][2][3][4]

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.[4]

Interactions[edit]

MAPRE1 has been shown to interact with TERF1.[5]

References[edit]

  1. ^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Aug 1995). "APC binds to the novel protein EB1". Cancer Res 55 (14): 2972–7. PMID 7606712. 
  2. ^ Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE (Sep 1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc Natl Acad Sci U S A 95 (18): 10596–601. doi:10.1073/pnas.95.18.10596. PMC 27940. PMID 9724749. 
  3. ^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr Biol 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. 
  4. ^ a b "Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1". 
  5. ^ Nakamura, Masafumi; Zhou X Z; Kishi Shuji; Lu K P (Mar 2002). "Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle". FEBS Lett. (Netherlands) 514 (2-3): 193–8. doi:10.1016/S0014-5793(02)02363-3. ISSN 0014-5793. PMID 11943150. 

Further reading[edit]