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Microtubule-associated protein, RP/EB family, member 2
Symbols MAPRE2 ; EB1; EB2; RP1
External IDs OMIM605789 MGI106271 HomoloGene75027 GeneCards: MAPRE2 Gene
RNA expression pattern
PBB GE MAPRE2 202501 at tn.png
PBB GE MAPRE2 213489 at tn.png
More reference expression data
Species Human Mouse
Entrez 10982 212307
Ensembl ENSG00000166974 ENSMUSG00000024277
UniProt Q15555 Q8R001
RefSeq (mRNA) NM_001143826 NM_001162941
RefSeq (protein) NP_001137298 NP_001156413
Location (UCSC) Chr 18:
32.56 – 32.72 Mb
Chr 18:
23.75 – 23.89 Mb
PubMed search [1] [2]

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.[1][2][3]


The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[3]


MAPRE2 has been shown to interact with APC.[4][5]


  1. ^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U et al. (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol 159 (3): 1276–83. PMID 9233623. 
  2. ^ Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC 138635. PMID 12475954. 
  3. ^ a b "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2". 
  4. ^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R et al. (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712. 
  5. ^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. 

Further reading[edit]