Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2gene.
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.
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^Su, L K; Burrell M, Hill D E, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler K W (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. (UNITED STATES) 55 (14): 2972–7. ISSN0008-5472. PMID7606712.Cite uses deprecated parameters (help)
Morrison EE, Wardleworth BN, Askham JM, et al. (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID10030671.
Wang Y, Zhou X, Zhu H, et al. (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID16007168.