The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.
^Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U et al. (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol159 (3): 1276–83. PMID9233623.
Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID10030671.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol.23 (1): 94–101. doi:10.1038/nbt1046. PMID15592455.
Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G et al. (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID16007168.