MARCM
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Mosaic analysis with a repressible cell marker, or MARCM, is a genetics technique for creating individually labeled homozygous cells in an otherwise heterozygous Drosophila melanogaster.[1] This technique relies on recombination during mitosis mediated by FLP-FRT Recombination. As one copy of a gene, provided by the balancer chromosome, is often enough to rescue a mutant phenotype, MARCM clones can be used to study a mutant phenotype in an otherwise normal animal.
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[edit] References
- ^ Lee, T; Luo, L (2001). "Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development". Trends in neurosciences 24 (5): 251–4. doi:10.1016/S0166-2236(00)01791-4. PMID 11311363.
