MARK2

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MAP/microtubule affinity-regulating kinase 2
Protein MARK2 PDB 1y8g.png
PDB rendering based on 1y8g.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MARK2 ; EMK-1; EMK1; PAR-1; Par-1b; Par1b
External IDs OMIM600526 MGI99638 HomoloGene69013 ChEMBL: 3831 GeneCards: MARK2 Gene
EC number 2.7.11.1, 2.7.11.26
Orthologs
Species Human Mouse
Entrez 2011 13728
Ensembl ENSG00000072518 ENSMUSG00000024969
UniProt Q7KZI7 Q05512
RefSeq (mRNA) NM_001039469 NM_001080388
RefSeq (protein) NP_001034558 NP_001073857
Location (UCSC) Chr 11:
63.61 – 63.68 Mb
Chr 19:
7.28 – 7.34 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.[1][2][3]

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.[3]

Interactions[edit]

MARK2 has been shown to interact with AKT1.[4]

References[edit]

  1. ^ Espinosa L, Navarro E (Oct 1998). "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet 81 (3–4): 278–82. doi:10.1159/000015046. PMID 9730619. 
  2. ^ Navarro E (Oct 1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet 86 (1): 66–7. doi:10.1159/000015413. PMID 10516437. 
  3. ^ a b "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". 
  4. ^ Dickey, Chad A; Koren John, Zhang Yong-Jie, Xu Ya-Fei, Jinwal Umesh K, Birnbaum Morris J, Monks Bobby, Sun Mei, Cheng Jin Q, Patterson Cam, Bailey Rachel M, Dunmore Judith, Soresh Sareh, Leon Carlos, Morgan Dave, Petrucelli Leonard (Mar 2008). "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (9): 3622–7. doi:10.1073/pnas.0709180105. PMC 2265134. PMID 18292230. 

Further reading[edit]