MASP2 (protein)

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Mannan-binding lectin serine peptidase 2
PDB 1q3x EBI.jpg
PDB rendering based on 1q3x.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MASP2 ; MAP19; MASP-2; MASP1P1; sMAP
External IDs OMIM605102 MGI1330832 HomoloGene4819 GeneCards: MASP2 Gene
EC number 3.4.21.104
Orthologs
Species Human Mouse
Entrez 10747 17175
Ensembl ENSG00000009724 ENSMUSG00000028979
UniProt O00187 Q91WP0
RefSeq (mRNA) NM_006610 NM_001003893
RefSeq (protein) NP_006601 NP_001003893
Location (UCSC) Chr 1:
11.09 – 11.11 Mb
Chr 4:
148.6 – 148.62 Mb
PubMed search [1] [2]

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.[1][2][3]

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.[1]

MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: mannan-binding lectin serine peptidase 2". 
  2. ^ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC; Vorup-Jensen; Stover; Schwaeble; Laursen; Poulsen; Willis; Eggleton; Hansen; Holmskov; Reid; Jensenius (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature 386 (6624): 506–10. Bibcode:1997Natur.386..506T. doi:10.1038/386506a0. PMID 9087411. 
  3. ^ Vorup-Jensen T, Jensenius JC, Thiel S (August 1998). "MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway". Immunobiology 199 (2): 348–57. doi:10.1016/S0171-2985(98)80039-9. PMID 9777418. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.