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Microtubule associated serine/threonine kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAST2 ; MAST205; MTSSK
External IDs OMIM612257 MGI894676 HomoloGene7428 IUPHAR: 1511 GeneCards: MAST2 Gene
EC number
RNA expression pattern
PBB GE MAST2 211593 s at tn.png
PBB GE MAST2 215660 s at tn.png
PBB GE MAST2 215903 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23139 17776
Ensembl ENSG00000086015 ENSMUSG00000003810
UniProt Q6P0Q8 Q60592
RefSeq (mRNA) NM_015112 NM_001042743
RefSeq (protein) NP_055927 NP_001036208
Location (UCSC) Chr 1:
46.25 – 46.5 Mb
Chr 4:
116.31 – 116.46 Mb
PubMed search [1] [2]

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.[1] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.[2]


MAST2 has been shown to interact with PCLKC.[3]


  1. ^ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2". 
  2. ^ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666. 
  3. ^ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771. 

Further reading[edit]