MCAT (gene)

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Malonyl CoA:ACP acyltransferase (mitochondrial)
Protein MCAT PDB 2c2n.png
PDB rendering based on 2c2n.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MCAT ; FASN2C; MCT; MT; NET62; fabD
External IDs OMIM614479 MGI2388651 HomoloGene15511 GeneCards: MCAT Gene
EC number 2.3.1.39
RNA expression pattern
PBB GE MCAT 213132 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27349 223722
Ensembl ENSG00000100294 ENSMUSG00000048755
UniProt Q8IVS2 Q8R3F5
RefSeq (mRNA) NM_014507 NM_001030014
RefSeq (protein) NP_055322 NP_001025185
Location (UCSC) Chr 22:
43.53 – 43.54 Mb
Chr 15:
83.55 – 83.56 Mb
PubMed search [1] [2]

Malonyl CoA-acyl carrier protein transacylase, mitochondrial is an enzyme that in humans is encoded by the MCAT gene.[1][2]

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ Zhang L, Joshi AK, Smith S (Oct 2003). "Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein". J Biol Chem 278 (41): 40067–74. doi:10.1074/jbc.M306121200. PMID 12882974. 
  2. ^ a b "Entrez Gene: MCAT malonyl CoA:ACP acyltransferase (mitochondrial)". 

Further reading[edit]