MCC (gene)

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Mutated in colorectal cancers
Identifiers
Symbols MCC ; MCC1
External IDs OMIM159350 HomoloGene20539 GeneCards: MCC Gene
RNA expression pattern
PBB GE MCC 206132 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4163 328949
Ensembl ENSG00000171444 ENSMUSG00000071856
UniProt P23508 E9PWI3
RefSeq (mRNA) NM_001085377 NM_001033406
RefSeq (protein) NP_001078846 NP_001078842
Location (UCSC) Chr 5:
112.36 – 112.82 Mb
Chr 18:
44.43 – 44.81 Mb
PubMed search [1] [2]

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[1][2]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370. 
  2. ^ a b "Entrez Gene: MCC mutated in colorectal cancers". 

Further reading[edit]