MCC (gene)

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Mutated in colorectal cancers
Symbols MCC ; MCC1
External IDs OMIM159350 HomoloGene20539 GeneCards: MCC Gene
RNA expression pattern
PBB GE MCC 206132 at tn.png
More reference expression data
Species Human Mouse
Entrez 4163 328949
Ensembl ENSG00000171444 ENSMUSG00000071856
UniProt P23508 E9PWI3
RefSeq (mRNA) NM_001085377 NM_001033406
RefSeq (protein) NP_001078846 NP_001078842
Location (UCSC) Chr 5:
112.36 – 112.82 Mb
Chr 18:
44.43 – 44.81 Mb
PubMed search [1] [2]

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[1][2]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370. 
  2. ^ a b "Entrez Gene: MCC mutated in colorectal cancers". 

Further reading[edit]