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Minichromosome maintenance complex component 10
Symbols MCM10 ; CNA43; DNA43
External IDs OMIM609357 MGI1917274 HomoloGene41275 GeneCards: MCM10 Gene
RNA expression pattern
PBB GE MCM10 220651 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55388 70024
Ensembl ENSG00000065328 ENSMUSG00000026669
UniProt Q7L590 Q0VBD2
RefSeq (mRNA) NM_018518 NM_027290
RefSeq (protein) NP_060988 NP_081566
Location (UCSC) Chr 10:
13.2 – 13.25 Mb
Chr 2:
4.99 – 5.01 Mb
PubMed search [1] [2]

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.[1][2][3]


The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[3]


MCM10 has been shown to interact with ORC2L.[1]


Further reading[edit]