MCM2

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"MCM-2" redirects here. For the warship, see USS Defender (MCM-2).
Minichromosome maintenance complex component 2
Identifiers
Symbols MCM2 ; BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
External IDs OMIM116945 MGI105380 HomoloGene3325 GeneCards: MCM2 Gene
EC number 3.6.4.12
RNA expression pattern
PBB GE MCM2 202107 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4171 17216
Ensembl ENSG00000073111 ENSMUSG00000002870
UniProt P49736 P97310
RefSeq (mRNA) NM_004526 NM_008564
RefSeq (protein) NP_004517 NP_032590
Location (UCSC) Chr 3:
127.32 – 127.34 Mb
Chr 6:
88.88 – 88.9 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.[1][2]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.[3]

See also[edit]

Interactions[edit]

MCM2 has been shown to interact with Replication protein A1,[4] AKAP8,[5] MCM5,[4][6] MCM6,[4][7][8][9][10] MCM7,[4][8][9][10][11] ORC1L,[4] ORC2L,[4] ORC4L,[4] ORC5L,[4] MCM4,[4][8][9][12] MCM3[4] and Cell division cycle 7-related protein kinase.[4]

References[edit]

  1. ^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453. 
  2. ^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304. 
  3. ^ "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)". 
  4. ^ a b c d e f g h i j k Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ Eide, Turid; Taskén Kristin A; Carlson Cathrine; Williams Gareth; Jahnsen Tore; Taskén Kjetil; Collas Philippe (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. (United States) 278 (29): 26750–6. doi:10.1074/jbc.M300765200. ISSN 0021-9258. PMID 12740381. 
  6. ^ DaFonseca, C J; Shu F; Zhang J J (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ a b c Yabuta, Norikazu; Kajimura Naoko; Mayanagi Kouta; Sato Michio; Gotow Takahito; Uchiyama Yasuo; Ishimi Yukio; Nojima Hiroshi (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. ISSN 1356-9597. PMID 12694531. 
  9. ^ a b c You, Z; Komamura Y; Ishimi Y (Dec 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526. 
  10. ^ a b You, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (Nov 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9. doi:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017. 
  11. ^ Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751. 
  12. ^ Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (Sep 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. ISSN 0021-9258. PMID 8798650. 

Further reading[edit]