MCM7

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Minichromosome maintenance complex component 7
Identifiers
Symbols MCM7 ; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
External IDs OMIM600592 MGI1298398 HomoloGene4323 GeneCards: MCM7 Gene
EC number 3.6.4.12
RNA expression pattern
PBB GE MCM7 208795 s at tn.png
PBB GE MCM7 210983 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4176 17220
Ensembl ENSG00000166508 ENSMUSG00000029730
UniProt P33993 Q61881
RefSeq (mRNA) NM_001278595 NM_008568
RefSeq (protein) NP_001265524 NP_032594
Location (UCSC) Chr 7:
99.69 – 99.7 Mb
Chr 5:
138.16 – 138.17 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]

Function[edit]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Interactions[edit]

MCM7 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Nakatsuru S, Sudo K, Nakamura Y (March 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet 68 (3-4): 226–30. doi:10.1159/000133918. PMID 7842741. 
  2. ^ "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)". 
  3. ^ a b c d e f g h i j k l m Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. 
  4. ^ Kukimoto I, Igaki H, Kanda T (November 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. PMID 10518787. 
  5. ^ a b Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M et al. (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337. 
  6. ^ a b c d e Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751. 
  7. ^ a b c Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y et al. (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. 
  8. ^ a b c You Z, Ishimi Y, Masai H, Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017. 
  9. ^ You Z, Komamura Y, Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. PMC 84885. PMID 10567526. 
  10. ^ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870. 
  11. ^ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650. 
  12. ^ DaFonseca CJ, Shu F, Zhang JJ (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027. 
  13. ^ Wang Y, Xu F, Hall FL (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. doi:10.1016/s0014-5793(00)02117-7. PMID 11056214. 
  14. ^ Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894. 
  15. ^ Kühne C, Banks L (December 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. 273 (51): 34302–9. doi:10.1074/jbc.273.51.34302. PMID 9852095. 

Further reading[edit]