MCM7

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Minichromosome maintenance complex component 7
Identifiers
Symbols MCM7 ; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
External IDs OMIM600592 MGI1298398 HomoloGene4323 GeneCards: MCM7 Gene
EC number 3.6.4.12
RNA expression pattern
PBB GE MCM7 208795 s at tn.png
PBB GE MCM7 210983 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4176 17220
Ensembl ENSG00000166508 ENSMUSG00000029730
UniProt P33993 Q61881
RefSeq (mRNA) NM_001278595 NM_008568
RefSeq (protein) NP_001265524 NP_032594
Location (UCSC) Chr 7:
99.69 – 99.7 Mb
Chr 5:
138.16 – 138.17 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

See also[edit]

Interactions[edit]

MCM7 has been shown to interact with Replication protein A1,[3] ORC3L,[3] Retinoblastoma protein,[4] MCM5,[3][5][6] MCM6,[3][5][7][8] ORC1L,[3] ORC2L,[3] ORC5L,[3] MCM4,[5][7][8][9] MCM3,[3][5][10][11] CDC6,[3][10] MNAT1,[12] DBF4,[3] MCM2,[3][5][7][8][13] UBE3A,[14] CDC45-related protein[3][15] and Cell division cycle 7-related protein kinase.[3]

References[edit]

  1. ^ Nakatsuru S, Sudo K, Nakamura Y (March 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet 68 (3-4): 226–30. doi:10.1159/000133918. PMID 7842741. 
  2. ^ "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)". 
  3. ^ a b c d e f g h i j k l m Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  4. ^ Sterner, J M; Dew-Knight S; Musahl C; Kornbluth S; Horowitz J M (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748–57. ISSN 0270-7306. PMC 110654. PMID 9566894. 
  5. ^ a b c d e Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751. 
  6. ^ DaFonseca, C J; Shu F; Zhang J J (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027. 
  7. ^ a b c Yabuta, Norikazu; Kajimura Naoko; Mayanagi Kouta; Sato Michio; Gotow Takahito; Uchiyama Yasuo; Ishimi Yukio; Nojima Hiroshi (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. ISSN 1356-9597. PMID 12694531. 
  8. ^ a b c You, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9. doi:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017. 
  9. ^ Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. ISSN 0021-9258. PMID 8798650. 
  10. ^ a b Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. ISSN 0021-9258. PMID 10464337. 
  11. ^ Fujita, Masatoshi; Ishimi Yukio; Nakamura Hiromu; Kiyono Tohru; Tsurumi Tatsuya (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–61. doi:10.1074/jbc.M111398200. ISSN 0021-9258. PMID 11779870. 
  12. ^ Wang, Y; Xu F; Hall F L (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. (NETHERLANDS) 484 (1): 17–21. doi:10.1016/S0014-5793(00)02117-7. ISSN 0014-5793. PMID 11056214. 
  13. ^ You, Z; Komamura Y; Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526. 
  14. ^ Kühne, C; Banks L (December 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. (UNITED STATES) 273 (51): 34302–9. doi:10.1074/jbc.273.51.34302. ISSN 0021-9258. PMID 9852095. 
  15. ^ Kukimoto, I; Igaki H; Kanda T (November 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. (GERMANY) 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. ISSN 0014-2956. PMID 10518787.