MCM7

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Minichromosome maintenance complex component 7
Identifiers
Symbols MCM7 ; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
External IDs OMIM600592 MGI1298398 HomoloGene4323 GeneCards: MCM7 Gene
EC number 3.6.4.12
RNA expression pattern
PBB GE MCM7 208795 s at tn.png
PBB GE MCM7 210983 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4176 17220
Ensembl ENSG00000166508 ENSMUSG00000029730
UniProt P33993 Q61881
RefSeq (mRNA) NM_001278595 NM_008568
RefSeq (protein) NP_001265524 NP_032594
Location (UCSC) Chr 7:
99.69 – 99.7 Mb
Chr 5:
138.16 – 138.17 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]

Function[edit]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Interactions[edit]

MCM7 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Nakatsuru S, Sudo K, Nakamura Y (March 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet 68 (3-4): 226–30. doi:10.1159/000133918. PMID 7842741. 
  2. ^ "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)". 
  3. ^ a b c d e f g h i j k l m Kneissl M, Pütter V, Szalay A, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. PMID 12614612. 
  4. ^ Kukimoto I, Igaki H, Kanda T (November 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. PMID 10518787. 
  5. ^ a b Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M et al. (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. PMID 10464337. 
  6. ^ a b c d e Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. PMID 9099751. 
  7. ^ a b c Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y et al. (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells 8 (5): 413–21. PMID 12694531. 
  8. ^ a b c You Z, Ishimi Y, Masai H, Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017. 
  9. ^ You Z, Komamura Y, Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. PMC 84885. PMID 10567526. 
  10. ^ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870. 
  11. ^ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. PMID 8798650. 
  12. ^ DaFonseca C, Shu F, Zhang J (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027. 
  13. ^ Wang Y, Xu F, Hall F (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. PMID 11056214. 
  14. ^ Sterner J, Dew-Knight S, Musahl C, Kornbluth S, Horowitz J (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894. 
  15. ^ Kühne C, Banks L (December 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. 273 (51): 34302–9. PMID 9852095. 

Further reading[edit]