Tyler grew to fame on the West Coast as one of two MCs in the four-man crew, Compton's Most Wanted. After enjoying increasing success with the group, which peaked with 1992's Music to Driveby, Eiht took a role in the hit movie Menace II Society as well as a high-profile spot on the soundtrack. The song, "Streiht Up Menace," which chronicles the unfortunate downturn of the film's protagonist within the pathological conditions of American inner city life, is considered by many critics to be Eiht's magnum opus. The movie spurred him into a solo career, although his next two albums We Come Strapped and Death Threatz would be accredited as MC Eiht featuring Compton's Most Wanted. These albums were considered his best and took place during the most tense years of the 'beef' between Eiht and DJ Quik, Eiht's childhood friends Boom Bam and Tha Chill of N.O.T.R were heavily involved with both albums and the Quik beef, there are several explicit remarks towards Quik made on these albums by E, Bam and Chill. E was also associated with W 159th St Tragniew Park Compton Crips.
He states that he did not wish to star in comedy films in order to maintain his public image. He later only appeared in the low-budget movies "Reasons," "Thicker Than Water" and "Who Made the Potato Salad?" as well as providing the voice for Lance 'Ryder' Wilson in the video game Grand Theft Auto: San Andreas.
He put out Last Man Standing, the first album accredited only to MC Eiht, then broke from the label for Big Beat/Atlantic. Eiht never ended up putting out an album on the label, instead eventually signing to and releasing the album Section 8 on Priority in 1999. Eiht would hop between record labels and one-off releases in the next years, moving between independent labels Half-Ounce, D3 Entertainment, and Lookin' Up Entertainment from 2001 to 2003. He would put out records with Spice 1 and Brotha Lynch Hung in 2004 and 2006 on Real Talk Ent., releasing another solo album between them on West Inc./Native Records. His inability to settle at a label contributed to his joining The Warzone, a trio put together by Snoop Dogg and consisting of Goldie Loc, Kam and MC Eiht himself. In 2006, Eiht and the group appeared on the single "Candy (Drippin' Like Water)" on Snoop Dogg's album Tha Blue Carpet Treatment. In 2010, Eiht appears on the remix to Dam Funk's "hood Pass Intact". MC Eiht also appeared with Young Maylay in Blaq Poet's new street single, Ain't Nuttin' Changed (Remix).
In June 2011, MC Eiht released his single "Fine By Me" accompanied by a music video directed by Director Hugo V. under his new label Year Round/Blue Stamp Records. Year Round Records is owned by New York based hip hop artist DJ Premier.