MDC1

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Mediator of DNA-damage checkpoint 1
Protein MDC1 PDB 2ado.png
PDB rendering based on 2ado.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MDC1 ; NFBD1
External IDs OMIM607593 MGI3525201 HomoloGene67092 GeneCards: MDC1 Gene
RNA expression pattern
PBB GE MDC1 203061 s at tn.png
PBB GE MDC1 203062 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9656 240087
Ensembl ENSG00000137337 ENSMUSG00000061607
UniProt Q14676 Q5PSV9
RefSeq (mRNA) NM_014641 NM_001010833
RefSeq (protein) NP_055456 NP_001010833
Location (UCSC) Chr 6:
30.67 – 30.69 Mb
Chr 17:
35.84 – 35.86 Mb
PubMed search [1] [2]

Mediator of DNA damage checkpoint protein 1 is a protein that in humans is encoded by the MDC1 gene.[1][2][3]

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.[3]

Interactions[edit]

MDC1 has been shown to interact with MRE11A,[4] H2AFX[2][4] and CHEK2.[5]

References[edit]

  1. ^ Ozaki T, Nagase T, Ichimiya S, Seki N, Ohiri M, Nomura N, Takada N, Sakiyama S, Weber BL, Nakagawara A (Sep 2000). "NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain". DNA Cell Biol 19 (8): 475–485. doi:10.1089/10445490050128403. PMID 10975465. 
  2. ^ a b Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (Feb 2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint". Nature 421 (6926): 961–966. doi:10.1038/nature01446. PMID 12607005. 
  3. ^ a b "Entrez Gene: MDC1 mediator of DNA damage checkpoint 1". 
  4. ^ a b Xu, Xingzhi; Stern David F (Oct 2003). "NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors". FASEB J. (United States) 17 (13): 1842–1848. doi:10.1096/fj.03-0310com. PMID 14519663. 
  5. ^ Lou, Zhenkun; Minter-Dykhouse Katherine, Wu Xianglin, Chen Junjie (Feb 2003). "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways". Nature (England) 421 (6926): 957–961. doi:10.1038/nature01447. ISSN 0028-0836. PMID 12607004. 

Further reading[edit]