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MDEA may refer to:
- Methyl diethanolamine (N-methyl-diethanolamine), CH3N(C2H4OH)2, a chemical used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulfide and carbon dioxide from gases in the petrochemical industry
- Methylenedioxyethylamphetamine (3,4-methylenedioxy-N-ethylamphetamine), C12H17NO2, an analog of MDMA
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