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MAM domain containing glycosylphosphatidylinositol anchor 2
Symbol MDGA2
Alt. symbols MAMDC1
Entrez 161357
HUGO 19835
OMIM 611128
RefSeq NM_182830
Other data
Locus Chr. 14 q21.2

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]

There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5]


  1. ^ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08. 
  2. ^ "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14. 
  3. ^ E. David Litwack, Regis Babey, Reto Buser, Matthias Gesemann & Dennis D. M. O'Leary (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943. 
  4. ^ "SNP linked to Gene MDGA2". NCBI. 
  5. ^ E. J. van den Oord, P. H. Kuo, A. M. Hartmann, B. T. Webb, H. J. Möller, J. M. Hettema, I. Giegling, J. Bukszár, D. Rujescu (September 2008). "18762592". Archives of General Psychiatry 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.