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Mediator complex subunit 16
Symbols MED16 ; DRIP92; THRAP5; TRAP95
External IDs OMIM604062 MGI2158394 HomoloGene64602 GeneCards: MED16 Gene
RNA expression pattern
PBB GE THRAP5 43544 at tn.png
PBB GE THRAP5 221418 s at tn.png
PBB GE THRAP5 221544 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10025 216154
Ensembl ENSG00000175221 ENSMUSG00000013833
UniProt Q9Y2X0 Q6PGF3
RefSeq (mRNA) NM_005481 NM_001163276
RefSeq (protein) NP_005472 NP_001156748
Location (UCSC) Chr 19:
0.87 – 0.89 Mb
Chr 10:
79.89 – 79.91 Mb
PubMed search [1] [2]

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.[1][2][3]


MED16 has been shown to interact with Thyroid hormone receptor alpha,[2] Estrogen receptor alpha[4] and Cyclin-dependent kinase 8.[2][4]


  1. ^ Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266. 
  2. ^ a b c Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638. 
  3. ^ "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5". 
  4. ^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. 

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