MED17

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Mediator complex subunit 17
Identifiers
Symbols MED17 ; CRSP6; CRSP77; DRIP80; TRAP80
External IDs OMIM603810 MGI2182585 HomoloGene3151 GeneCards: MED17 Gene
Orthologs
Species Human Mouse
Entrez 9440 234959
Ensembl ENSG00000042429 ENSMUSG00000031935
UniProt Q9NVC6 Q8VCD5
RefSeq (mRNA) NM_004268 NM_144933
RefSeq (protein) NP_004259 NP_659182
Location (UCSC) Chr 11:
93.52 – 93.55 Mb
Chr 9:
15.26 – 15.28 Mb
PubMed search [1] [2]

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.[1][2][3]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[3]

Interactions[edit]

MED17 has been shown to interact with PPARGC1A,[4] Cyclin-dependent kinase 8[2][5] and BRCA1.[6][7][8]

References[edit]

  1. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412. 
  2. ^ a b Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638. 
  3. ^ a b "Entrez Gene: CRSP6 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa". 
  4. ^ Wallberg, Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G (Nov 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell (United States) 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. ISSN 1097-2765. PMID 14636573. 
  5. ^ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. 
  6. ^ Chiba, N; Parvin J D (Oct 2001). "Redistribution of BRCA1 among four different protein complexes following replication blockage". J. Biol. Chem. (United States) 276 (42): 38549–54. doi:10.1074/jbc.M105227200. ISSN 0021-9258. PMID 11504724. 
  7. ^ Wada, Osamu; Oishi Hajime; Takada Ichiro; Yanagisawa Junn; Yano Tetsu; Kato Shigeaki (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene (England) 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. ISSN 0950-9232. PMID 15208681. 
  8. ^ Chiba, Natsuko; Parvin Jeffrey D (Aug 2002). "The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme". Cancer Res. (United States) 62 (15): 4222–8. ISSN 0008-5472. PMID 12154023. 

Further reading[edit]