From Wikipedia, the free encyclopedia
Jump to: navigation, search
Mediator complex subunit 22
Symbols MED22 ; MED24; SURF5; surf-5
External IDs OMIM185641 MGI98446 HomoloGene4913 GeneCards: MED22 Gene
RNA expression pattern
PBB GE SURF5 206593 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6837 20933
Ensembl ENSG00000148297 ENSMUSG00000015776
UniProt Q15528 Q62276
RefSeq (mRNA) NM_006752 NM_001033908
RefSeq (protein) NP_598395 NP_001029080
Location (UCSC) Chr 9:
136.21 – 136.21 Mb
Chr 2:
26.91 – 26.91 Mb
PubMed search [1] [2]

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.[1][2][3]

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.[3]


MED22 has been shown to interact with MED30.[4]


  1. ^ Yon J, Jones T, Garson K, Sheer D, Fried M (Jun 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum Mol Genet 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913. 
  2. ^ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163. 
  3. ^ a b "Entrez Gene: SURF5 surfeit 5". 
  4. ^ Sato, Shigeo; Tomomori-Sato Chieri, Banks Charles A S, Sorokina Irina, Parmely Tari J, Kong Stephanie E, Jin Jingji, Cai Yong, Lane William S, Brower Christopher S, Conaway Ronald C, Conaway Joan Weliky (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. (United States) 278 (17): 15123–7. doi:10.1074/jbc.C300054200. ISSN 0021-9258. PMID 12584197. 

Further reading[edit]