MEF2B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MEF2BNB-MEF2B readthrough
Protein MEF2B PDB 1egw.png
PDB rendering based on 1egw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MEF2BNB-MEF2B ; LOC729991-MEF2B; MEF2B
External IDs OMIM600661 MGI104526 HomoloGene48381 GeneCards: MEF2BNB-MEF2B Gene
Orthologs
Species Human Mouse
Entrez 4207 17259
Ensembl ENSG00000213999 n/a
UniProt Q02080 n/a
RefSeq (mRNA) NM_005919 NM_001045484
RefSeq (protein) NP_005910 NP_001038949
Location (UCSC) Chr 19:
19.26 – 19.3 Mb
n/a
PubMed search [1] [2]

MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), also known as MEF2B, is a human gene.[1]


Interactions[edit]

MEF2B has been shown to interact with CABIN1.[2][3]

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[4][5]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: MEF2B MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)". 
  2. ^ Han, Aidong; Pan Fan; Stroud James C; Youn Hong-Duk; Liu Jun O; Chen Lin (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature (England) 422 (6933): 730–4. doi:10.1038/nature01555. ISSN 0028-0836. PMID 12700764. 
  3. ^ Youn, H D; Sun L; Prywes R; Liu J O (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science (UNITED STATES) 286 (5440): 790–3. doi:10.1126/science.286.5440.790. ISSN 0036-8075. PMID 10531067. 
  4. ^ Morin, Ryan D.; Mendez-Lago, Maria; Mungall, Andrew J.; Goya, Rodrigo; Mungall, Karen L.; Corbett, Richard D.; Johnson, Nathalie A.; Severson, Tesa M.; Chiu, Readman; Field, Matthew; Jackman, Shaun; Krzywinski, Martin; Scott, David W.; Trinh, Diane L.; Tamura-Wells, Jessica; Li, Sa; Firme, Marlo R.; Rogic, Sanja; Griffith, Malachi; Chan, Susanna; Yakovenko, Oleksandr; Meyer, Irmtraud M.; Zhao, Eric Y.; Smailus, Duane; Moksa, Michelle; Chittaranjan, Suganthi; Rimsza, Lisa; Brooks-Wilson, Angela; Spinelli, John J.; Ben-Neriah, Susana; Meissner, Barbara; Woolcock, Bruce; Boyle, Merrill; McDonald, Helen; Tam, Angela; Zhao, Yongjun; Delaney, Allen; Zeng, Thomas; Tse, Kane; Butterfield, Yaron; Birol, Inanç; Holt, Rob; Schein, Jacqueline; Horsman, Douglas E.; Moore, Richard; Jones, Steven J. M.; Connors, Joseph M.; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A. (2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. doi:10.1038/nature10351. ISSN 0028-0836. PMC 3210554. PMID 21796119. 
  5. ^ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (Feb 17, 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]

External links[edit]