MEF2D

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Myocyte enhancer factor 2D
Protein MEF2D PDB 1c7u.png
PDB rendering based on 1c7u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MEF2D ; DKFZp686I1536
External IDs OMIM600663 MGI99533 HomoloGene4327 GeneCards: MEF2D Gene
RNA expression pattern
PBB GE MEF2D 203003 at tn.png
PBB GE MEF2D 203004 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4209 17261
Ensembl ENSG00000116604 ENSMUSG00000001419
UniProt Q14814 Q63943
RefSeq (mRNA) NM_001271629 NM_133665
RefSeq (protein) NP_001258558 NP_598426
Location (UCSC) Chr 1:
156.43 – 156.47 Mb
Chr 3:
88.14 – 88.17 Mb
PubMed search [1] [2]

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[1][2]


Interactions[edit]

MEF2D has been shown to interact with YWHAQ,[3] MAPK7,[4] EP300,[5][6] Sp1 transcription factor,[7] Myocyte-specific enhancer factor 2A,[8] NFATC2[9] and CABIN1.[6][10]

See also[edit]

References[edit]

  1. ^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (February 1994). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development 118 (4): 1095–106. PMID 8269842. 
  2. ^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". 
  3. ^ Choi, S J; Park S Y; Han T H (July 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Res. (England) 29 (13): 2836–42. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030. 
  4. ^ Yang, C C; Ornatsky O I; McDermott J C; Cruz T F; Prody C A (October 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. (ENGLAND) 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. ISSN 0305-1048. PMC 147902. PMID 9753748. 
  5. ^ Youn, H D; Grozinger C M; Liu J O (July 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". J. Biol. Chem. (UNITED STATES) 275 (29): 22563–7. doi:10.1074/jbc.C000304200. ISSN 0021-9258. PMID 10825153. 
  6. ^ a b Youn, H D; Liu J O (July 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity (UNITED STATES) 13 (1): 85–94. doi:10.1016/S1074-7613(00)00010-8. ISSN 1074-7613. PMID 10933397. 
  7. ^ Park, So-Youn; Shin Hyun-Mu; Han Tae-Hee (September 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Mol. Immunol. (England) 39 (1-2): 25–30. doi:10.1016/S0161-5890(02)00055-X. ISSN 0161-5890. PMID 12213324. 
  8. ^ Ornatsky, O I; McDermott J C (October 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. (UNITED STATES) 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. ISSN 0021-9258. PMID 8798771. 
  9. ^ Youn, H D; Chatila T A; Liu J O (August 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". EMBO J. (ENGLAND) 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. ISSN 0261-4189. PMC 302027. PMID 10944115. 
  10. ^ Youn, H D; Sun L; Prywes R; Liu J O (October 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science (UNITED STATES) 286 (5440): 790–3. doi:10.1126/science.286.5440.790. ISSN 0036-8075. PMID 10531067. 

Further reading[edit]

External links[edit]