MELK
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| Maternal embryonic leucine zipper kinase | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MELK; HPK38; KIAA0175 | ||||||||||||
| External IDs | OMIM: 607025 MGI: 106924 HomoloGene: 32111 GeneCards: MELK Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9833 | 17279 | |||||||||||
| Ensembl | ENSG00000165304 | ENSMUSG00000035683 | |||||||||||
| UniProt | Q14680 | Q3TJF3 | |||||||||||
| RefSeq (mRNA) | NM_014791 | NM_010790.2 | |||||||||||
| RefSeq (protein) | NP_055606 | NP_034920.2 | |||||||||||
| Location (UCSC) | Chr 9: 36.57 – 36.68 Mb |
Chr 4: 44.31 – 44.38 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.[1][2][3]
[edit] Interactions
MELK has been shown to interact with CDC25B.[4]
[edit] References
- ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
- ^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
- ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9833.
- ^ Davezac, Noélie; Baldin Véronique, Blot Joëlle, Ducommun Bernard, Tassan Jean-Pierre (Oct. 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene (England) 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN 0950-9232. PMID 12400006.
[edit] Further reading
- Lin ML, Park JH, Nishidate T, et al. (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384. PMID 17280616. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1851384.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Beullens M, Vancauwenbergh S, Morrice N, et al. (2006). "Substrate specificity and activity regulation of protein kinase MELK.". J. Biol. Chem. 280 (48): 40003–11. doi:10.1074/jbc.M507274200. PMID 16216881.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Vulsteke V, Beullens M, Boudrez A, et al. (2004). "Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1.". J. Biol. Chem. 279 (10): 8642–7. doi:10.1074/jbc.M311466200. PMID 14699119.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Davezac N, Baldin V, Blot J, et al. (2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.". Oncogene 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.
- Seong HA, Gil M, Kim KT, et al. (2002). "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).". Biochem. J. 361 (Pt 3): 597–604. doi:10.1042/0264-6021:3610597. PMC 1222342. PMID 11802789. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222342.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Gil M, Yang Y, Lee Y, et al. (1997). "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells". Gene 195 (2): 295–301. doi:10.1016/S0378-1119(97)00181-9. PMID 9305775.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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