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MER proto-oncogene, tyrosine kinase
Protein MERTK PDB 2dbj.png
PDB rendering based on 2dbj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MERTK ; MER; RP38; c-mer
External IDs OMIM604705 MGI96965 HomoloGene4626 ChEMBL: 5331 GeneCards: MERTK Gene
EC number
Species Human Mouse
Entrez 10461 17289
Ensembl ENSG00000153208 ENSMUSG00000014361
UniProt Q12866 Q60805
RefSeq (mRNA) NM_006343 NM_008587
RefSeq (protein) NP_006334 NP_032613
Location (UCSC) Chr 2:
112.66 – 112.79 Mb
Chr 2:
128.7 – 128.8 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.[1][2][3]

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).[3]


  1. ^ Graham DK, Dawson TL, Mullaney DL, Snodgrass HR, Earp HS (Oct 1994). "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer". Cell Growth Differ 5 (6): 647–57. PMID 8086340. 
  2. ^ Weier HU, Fung J, Lersch RA (Jun 1999). "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization". Cytogenet Cell Genet 84 (1–2): 91–2. doi:10.1159/000015223. PMID 10343112. 
  3. ^ a b "Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase". 

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