MEX3D

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Mex-3 homolog D (C. elegans)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MEX3D ; MEX-3D; MEX3; OK/SW-cl.4; RKHD1; RNF193; TINO
External IDs OMIM611009 MGI2681847 HomoloGene16890 GeneCards: MEX3D Gene
Orthologs
Species Human Mouse
Entrez 399664 237400
Ensembl ENSG00000181588 ENSMUSG00000048696
UniProt Q86XN8 Q3UE17
RefSeq (mRNA) NM_001174118 NM_198615
RefSeq (protein) NP_001167589 NP_941017
Location (UCSC) Chr 19:
1.55 – 1.57 Mb
Chr 10:
80.38 – 80.39 Mb
PubMed search [1] [2]

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[1][2]

Function[edit]

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[2]

Structure[edit]

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[2]

References[edit]

  1. ^ "Entrez Gene: mex-3 homolog D (C. elegans)". 
  2. ^ a b c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789. 

Further reading[edit]