Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene. [1 ] [2 ]
Function [ edit ]
MEX3D is an RNA binding protein that interacts with
AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level. [2 ]
Structure [ edit ]
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs (
KH domain ) and a RING domain at the C-terminus. [2 ]
References [ edit ]
Further reading [ edit ]
Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Buchet-Poyau K, Courchet J, Le Hir H et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.". Nucleic Acids Res. 35 (4): 1289–300. doi: 10.1093/nar/gkm016. PMC 1851655. PMID 17267406.