MFGE8

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Milk fat globule-EGF factor 8 protein
Identifiers
Symbols MFGE8 ; BA46; EDIL1; HMFG; HsT19888; MFG-E8; MFGM; OAcGD3S; SED1; SPAG10; hP47
External IDs OMIM602281 MGI102768 HomoloGene4334 GeneCards: MFGE8 Gene
RNA expression pattern
PBB GE MFGE8 210605 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4240 17304
Ensembl ENSG00000140545 ENSMUSG00000030605
UniProt Q08431 P21956
RefSeq (mRNA) NM_001114614 NM_001045489
RefSeq (protein) NP_001108086 NP_001038954
Location (UCSC) Chr 15:
89.44 – 89.46 Mb
Chr 7:
79.13 – 79.15 Mb
PubMed search [1] [2]

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.[1][2]

Species distribution[edit]

Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.

Function[edit]

MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fiber in arteries.[3] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[4] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[5] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[6]

MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.

References[edit]

  1. ^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein". 
  2. ^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496. 
  3. ^ Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P (June 2006). "Lactadherin binds to elastin--a starting point for medin amyloid formation?". Amyloid 13 (2): 78–85. doi:10.1080/13506120600722530. PMID 16911961. 
  4. ^ Peng S, Glennert J, Westermark P (June 2005). "Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body". Amyloid 12 (2): 96–102. doi:10.1080/13506120500107006. PMID 16011985. 
  5. ^ Silvestre JS, Théry C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Lévy B, Tedgui A, Amigorena S, Mallat Z (May 2005). "Lactadherin promotes VEGF-dependent neovascularization". Nat. Med. 11 (5): 499–506. doi:10.1038/nm1233. PMID 15834428. 
  6. ^ Raymond A, Ensslin MA, Shur BD (April 2009). "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions". J. Cell. Biochem. 106 (6): 957–66. doi:10.1002/jcb.22076. PMC 2742659. PMID 19204935. 

Further reading[edit]