MG132
From Wikipedia, the free encyclopedia
| MG132 | |
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Other names
N-(benzyloxycarbonyl)leucinylleucinylleucinal |
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| Identifiers | |
| CAS number | 133407-82-6 |
| Properties | |
| Molecular formula | C26H41N3O5 |
| Molar mass | 475.62 g mol−1 |
| Appearance | white solid |
| Solubility | 100 mM in EtOH and DMSO |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage.
