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Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
External IDs OMIM602616 MGI2384966 HomoloGene1806 GeneCards: MGAT2 Gene
EC number
RNA expression pattern
PBB GE MGAT2 203102 s at tn.png
PBB GE MGAT2 203101 s at tn.png
PBB GE MGAT2 211061 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4247 217664
Ensembl ENSG00000168282 ENSMUSG00000043998
UniProt Q10469 Q921V5
RefSeq (mRNA) NM_001015883 NM_146035
RefSeq (protein) NP_002399 NP_666147
Location (UCSC) Chr 14:
50.09 – 50.09 Mb
Chr 12:
69.18 – 69.19 Mb
PubMed search [1] [2]

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene.[1][2]

The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined.[2]


  1. ^ Tan J, D'Agostaro AF, Bendiak B, Reck F, Sarkar M, Squire JA, Leong P, Schachter H (Sep 1995). "The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein". Eur J Biochem 231 (2): 317–28. doi:10.1111/j.1432-1033.1995.tb20703.x. PMID 7635144. 
  2. ^ a b "Entrez Gene: MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase". 

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