MGAT3

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Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Identifiers
Symbols MGAT3 ; GNT-III; GNT3
External IDs OMIM604621 MGI104532 HomoloGene31088 GeneCards: MGAT3 Gene
EC number 2.4.1.144
RNA expression pattern
PBB GE MGAT3 208058 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4248 17309
Ensembl ENSG00000128268 ENSMUSG00000042428
UniProt Q09327 Q5RKT9
RefSeq (mRNA) NM_001098270 NM_010795
RefSeq (protein) NP_001091740 NP_034925
Location (UCSC) Chr 22:
39.46 – 39.49 Mb
Chr 15:
80.17 – 80.22 Mb
PubMed search [1] [2]

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.[1][2]

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

References[edit]

  1. ^ Ihara Y, Nishikawa A, Tohma T, Soejima H, Niikawa N, Taniguchi N (Oct 1993). "cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III)". J Biochem 113 (6): 692–8. PMID 8370666. 
  2. ^ a b "Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase". 

Further reading[edit]