MHC class I polypeptide-related sequence A

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MHC class I polypeptide-related sequence A
PBB Protein MICA image.jpg
PDB rendering based on 1b3j.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MICA ; MIC-A; PERB11.1
External IDs OMIM600169 MGI2179989 HomoloGene129888 GeneCards: MICA Gene
RNA expression pattern
PBB GE MICA 205904 at tn.png
PBB GE MICA 205905 s at tn.png
More reference expression data
Species Human Mouse
Entrez 100507436 243864
Ensembl ENSG00000183214 n/a
UniProt Q29983 n/a
RefSeq (mRNA) NM_000247 XM_985890
RefSeq (protein) NP_000238 XP_990984
Location (UCSC) Chr 6:
31.37 – 31.38 Mb
PubMed search [1] [2]

MHC class I polypeptide-related sequence A is a protein that in humans is encoded by the MICA gene.[1]

MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells.[2] MICA is a ligand for NK cell activating receptor NKG2D.[3]

See also[edit]


  1. ^ Bahram S, Bresnahan M, Geraghty DE, Spies T (Aug 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proc Natl Acad Sci U S A 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771. 
  2. ^ "Entrez Gene: MICA MHC class I polypeptide-related sequence A". 
  3. ^ González, S et al. (2008). "NKG2D ligands: key targets of the immune response". Trends in Immunology 29 (8). doi:10.1016/ PMID 18602338. 

Further reading[edit]