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Midline 2
Protein MID2 PDB 2dja.png
PDB rendering based on 2dja.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MID2 ; FXY2; RNF60; TRIM1
External IDs OMIM300204 MGI1344333 HomoloGene8028 GeneCards: MID2 Gene
RNA expression pattern
PBB GE MID2 208384 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11043 23947
Ensembl ENSG00000080561 ENSMUSG00000000266
UniProt Q9UJV3 Q9QUS6
RefSeq (mRNA) NM_012216 NM_011845
RefSeq (protein) NP_036348 NP_035975
Location (UCSC) Chr X:
107.07 – 107.17 Mb
Chr X:
140.66 – 140.77 Mb
PubMed search [1] [2]

Midline-2 is a protein that in humans is encoded by the MID2 gene.[1][2]


The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]


MID2 has been shown to interact with MID1.[3][4]


  1. ^ Buchner G, Montini E, Andolfi G, Quaderi N, Cainarca S, Messali S et al. (Sep 1999). "MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development". Hum Mol Genet 8 (8): 1397–407. doi:10.1093/hmg/8.8.1397. PMID 10400986. 
  2. ^ a b "Entrez Gene: MID2 midline 2". 
  3. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L et al. (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580. 
  4. ^ Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biol. 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779. PMID 11806752. 

Further reading[edit]