MIR627

MIR627
Identifiers
Aliases	MIR627, MIRN627, hsa-mir-627, mir-627, microRNA 627
External IDs	GeneCards: MIR627
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 42,199,570 bp End 42,199,666 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve liver blood muscle of leg Achilles tendon body of pancreas endometrium heart left uterine tube gastrocnemius muscle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 693212 n/a Ensembl ENSG00000207712 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 15: 42.2 – 42.2 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

MicroRNA 627 is a protein that in humans is encoded by the MIR627 gene.

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.