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MAP kinase interacting serine/threonine kinase 1
Protein MKNK1 PDB 2hw6.png
PDB rendering based on 2hw6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MKNK1 ; MNK1
External IDs OMIM606724 MGI894316 HomoloGene37838 ChEMBL: 4718 GeneCards: MKNK1 Gene
EC number
RNA expression pattern
PBB GE MKNK1 209467 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8569 17346
Ensembl ENSG00000079277 ENSMUSG00000028708
UniProt Q9BUB5 O08605
RefSeq (mRNA) NM_001135553 NM_021461
RefSeq (protein) NP_001129025 NP_067436
Location (UCSC) Chr 1:
47.02 – 47.08 Mb
Chr 4:
115.84 – 115.88 Mb
PubMed search [1] [2]

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.[1][2]


MKNK1 has been shown to interact with MAPK1[3] and Eukaryotic translation initiation factor 4 gamma.[4]


  1. ^ Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018. 
  2. ^ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1". 
  3. ^ Waskiewicz, A J; Flynn A, Proud C G, Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. (ENGLAND) 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017. 
  4. ^ Pyronnet, S; Imataka H, Gingras A C, Fukunaga R, Hunter T, Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. (ENGLAND) 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069. 

Further reading[edit]