MLF1
From Wikipedia, the free encyclopedia
| Myeloid leukemia factor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MLF1; | ||||||||||||
| External IDs | OMIM: 601402 MGI: 1341819 HomoloGene: 7839 GeneCards: MLF1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4291 | 17349 | |||||||||||
| Ensembl | ENSG00000178053 | ENSMUSG00000048416 | |||||||||||
| UniProt | P58340 | Q3V042 | |||||||||||
| RefSeq (mRNA) | NM_001130156.2 | NM_001039543 | |||||||||||
| RefSeq (protein) | NP_001123628.1 | NP_001034632 | |||||||||||
| Location (UCSC) | Chr 3: 158.29 – 158.33 Mb |
Chr 3: 67.18 – 67.2 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.[1][2]
[edit] References
- ^ Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene 12 (2): 265–75. PMID 8570204.
- ^ "Entrez Gene: MLF1 myeloid leukemia factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4291.
[edit] Further reading
- Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.". J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Arber DA, Chang KL, Lyda MH, et al. (2003). "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia.". Hum. Pathol. 34 (8): 809–13. doi:10.1016/S0046-8177(03)00251-X. PMID 14506644.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hanissian SH, Akbar U, Teng B, et al. (2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.". Oncogene 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Yoneda-Kato N, Tomoda K, Umehara M, et al. (2005). "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.". EMBO J. 24 (9): 1739–49. doi:10.1038/sj.emboj.7600656. PMC 1142586. PMID 15861129. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142586.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Yoneda-Kato N, Kato JY (2008). "Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06. PMC 2223285. PMID 17967869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2223285.
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