Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
MMP10 has been linked to cancer stem cell vitality and metastasis 
Chandler S, Miller KM, Clements JM, et al. (1997). "Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview". J. Neuroimmunol.72 (2): 155–61. doi:10.1016/S0165-5728(96)00179-8. PMID9042108.
Fosang AJ, Neame PJ, Hardingham TE, et al. (1991). "Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins". J. Biol. Chem.266 (24): 15579–82. PMID1874716.
Sirum KL, Brinckerhoff CE (1990). "Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts". Biochemistry28 (22): 8691–8. doi:10.1021/bi00448a004. PMID2605216.
Lichtinghagen R, Helmbrecht T, Arndt B, Böker KH (1995). "Expression pattern of matrix metalloproteinases in human liver". European Journal of Clinical Chemistry and Clinical Biochemistry33 (2): 65–71. doi:10.1515/cclm.1918.104.22.168. PMID7632822.
Gack S, Vallon R, Schaper J, et al. (1994). "Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein". J. Biol. Chem.269 (14): 10363–9. PMID8144618.
Windsor LJ, Grenett H, Birkedal-Hansen B, et al. (1993). "Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters". J. Biol. Chem.268 (23): 17341–7. PMID8349617.
Pendás AM, Santamaría I, Alvarez MV, et al. (1997). "Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3". Genomics37 (2): 266–8. doi:10.1006/geno.1996.0557. PMID8921407.
Sorsa T, Salo T, Koivunen E, et al. (1997). "Activation of type IV procollagenases by human tumor-associated trypsin-2". J. Biol. Chem.272 (34): 21067–74. doi:10.1074/jbc.272.34.21067. PMID9261109.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Nakamura H, Fujii Y, Ohuchi E, et al. (1998). "Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases". Eur. J. Biochem.253 (1): 67–75. doi:10.1046/j.1432-1327.1998.2530067.x. PMID9578462.
Bord S, Horner A, Hembry RM, Compston JE (1998). "Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development". Bone23 (1): 7–12. doi:10.1016/S8756-3282(98)00064-7. PMID9662124.